Thyretain TSI Reporter BioAssay - Thyroid Testing Solutions
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Thyretain™ - Thyroid Stimulating Immunoglobulin Reporter BioAssay
Thyroid Stimulating Immunoglobulins (TSI) are linked to an autoimmune thyroid disorder called Graves’ disease1. In this disease, the TSI bind to the thyroid stimulating hormone (TSH) receptors (TSHR) of the thyroid gland, causing an over-production of thyroid hormones. This can lead to a number of different symptoms, making the initial diagnosis of thyroid disorders difficult2. However, the specific detection of TSI in conjunction with other clinical determinations can be used for differential diagnosis of Graves’ disease. Once diagnosed, the disease has a variety of treatment options3.
Diagnostic Hybrids’ Thyretain specifically detects TSI in a user-friendly format
- Specific, sensitive and reproducible test results
- Simplified cell culture techniques utilizing DHI frozen cell culture technology
- Use of whole serum eliminates the need for IgG purification, saving time and money
- Results in 3 to 4 hours assures a quick turnaround time in the lab
References
1 Takasu N, Yamashiro K, Komiya I, Ochi Y, Sato Y, Nagata A. 2000. Remission of Graves’ hyperthyroidism predicted by smooth decreases of thyroid stimulating antibody and thyrotropin binding inhibitor immunoglobulin during antithyroid drug treatment. Thyroid 10:891-896.
2 Godfrey, J. (2004) Toward Optimal Health: The Experts Discuss Thyroid Disfunction. Journal of Women’s Health, Vol. 13 Issue 2, p. 141-146.
3 Gittoes, NJL, Franklyn, JA. 1998. Hyperthyroidism: Current Treatment Guidelines. Drugs 55:543-553.
Product Codes
40-25000.v2 Thyretain TSI Reporter BioAssay capable of testing 25 plates
Includes: Thyretain FreshFrozenCells and Control Set (1), Thyretain Media Set (1), Luciferase Assay Reagent Set (10)
40-50000.v2 Thyretain TSI Reporter BioAssay capable of testing 50 plates
Includes: Thyretain FreshFrozenCells and Control Set (1), Thyretain Media Set (2), Luciferase Assay Reagent Set (20)
Educational Resources
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Clinical Evaluation of Thyroid Stimulating Autoantibody (TSAb) Reporter Assay Using Chimeric TSH Receptor Transfected CHO Cell Line: Comparison with Radio Receptor Binding Assay
Rosemary Lounsbury and Manjula Gupta. Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA. Download File
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Detection of Serum Thyroid Stimulating Immunoglobulin (TSI) in Graves' Disease (GD) Using a Novel Cell-Based Reporter Assay
L Grippa1, J Stockwell1, R Kelly1, JA Houtz1, J Brown1, D Scholl1, and LD Kohn2, Y Li1. 1Diagnostic Hybrids, Athens, OH, and 2Interthyr Corporation, Athens, OH. Download File
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Development of a Novel Reporter Cell Line and a Standardized Protocol for the Detection of Thyroid Stimulating Immunoglobulin (TSI)
James Stockwell1, Lauren Grippa1, Teresa Curtiss1, Abby Jones1, Ruth Kelly1, Audrey Larrimer1, Christopher Lewis1, Doug Wylie1, Misako Hata1, Steve Ewers1, Jeffery Houtz1, Gabby Sanders1, Leonard Kohn2, Yunsheng Li1. 1Research & Development, Diagnostic Hybrids, Athens, OH,USA, and 2Research & Development, Interthyr Corporation, Athens, OH, USA. Download File
